What is spermidine?

Spermidine is a polyamine, an organic compound consisting of two or more amino groups, which is positively charged at physiological pH. Spermidine is present in all human tissues. There are three sources of spermidine:

  • endogenous spermidine made from the precursor amino acid ornithine;
  • microbial spermidine, produced from gut microbes, and
  • dietary spermidine, naturally occurring in food.

Endogenous production of spermidine accounts for roughly 1/3 of the body’s spermidine, however the ability to produce spermidine endogenously decreases with age. While microbial and dietary intakes make up 2/3 of the body’s needs, dietary intakes vary greatly between countries, with spermidine intake being higher on the Mediterranean and Japanese diets than on the typical American or Western European diet. 

What are the best dietary sources of spermidine?

With respect to food sources, spermidine is found in the greatest amounts in wheat germ and fermented soy (e.g. natto and tempe). Wheat germ, in particular, has a very high spermidine content and the wheat germ in Primeadine® has a beneficial ratio of spermidine to the other polyamines, spermine and putrescine. Wheat germ derived spermidine is also well absorbed in the GI tract due to its high molecular mass.

Is Primeadine® a substitute for eating a balanced diet? 

No, this is a supplement to a balanced diet. It is not in any way a replacement for a balanced diet. 

How long will it take for me to see results?

Best effects are typically seen after 2 months.

How will I know that it's working for me?

In clinical studies, hair is the first place where spermidine leads to physically noticeable changes. 

Individual results will vary.

How often do I need to take it to experience benefits?

We recommend that Primeadine® be taken once a day together with food. Results will vary from person to person

How clean is your product?

We manufacture our Primeadine® spermidine in Japan in a Japanese Good Manufacturing Practices compliant facility. Quality, purity and other assurance tests are conducted in Japan. Once our product arrives in the United States, it must undergo another round of quality assurance tests to ensure there are no toxins or other impurities present. It is then encapsulated and bottled in a US GMP compliant manufacturing facility.

Where can I buy this product?

Orders are available from our website, which offers secure payment through Shopify. 

Does it contain wheat or gluten?

Yes, it contains both.The amount of gluten per serving size is <40mgs. A standard slice of American bread will have between 1,000-2,000mgs of gluten. Primeadine® contains 1/50th to 1/100th the amount of gluten in a single slice of bread. 

I’m coeliac. Is this appropriate for me?

No, Primeadine® is not suitable for coeliacs.

I have been diagnosed with Small Intestinal Bacterial Overgrowth (SIBO). Is this appropriate for me? 

Primeadine® is a source of FODMAP's and may not be suitable for individuals with SIBO. Consult your healthcare provider to see whether Primeadine® is suitable for you.

Does Primeadine® contain FODMAP's?

Yes, Primeadine® is a concentrated wheat germ supplement and, like all wheat germ, contains FODMAP's. Primeadine® may not be suitable for individuals on a low FODMAP diet. Consult with your healthcare provider to see whether Primeadine® is suitable for you. 

Is spermidine a medical treatment?

No. It is a naturally occurring compound that can be derived from food sources. It is in no way classed as medical treatment.

Is there a Primeadine® monthly subscription plan?

We do not currently offer a monthly subscription plan. A monthly subscription plan requires us to ship out a single bottle every month, which increases the carbon footprint. However, we do offer a 2 month supply as well as a 3 month supply, in which multiple bottles are shipped in the same package.

Are Primeadine® bottles recyclable?

Yes, all of our Primeadine® bottles are made of grade 1 Polyethylene terephthalate (PET or PETE).


These statements have not been evaluated by the US Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.